Zip71B Zinc/iron regulated transporter-related protein 71B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zip71Bprovided by FlyBase
Official Full Name: Zinc/iron regulated transporter-related protein 71Bprovided by FlyBase
Primary source: FLYBASE:FBgn0036461
Locus tag: Dmel_CG10006
See related: AllianceGenome:FB:FBgn0036461
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg10006; CG10006; Dmel\CG10006; dZip71B; Slc39a10; ZIP10; ZIP71B
Summary: Enables zinc ion transmembrane transporter activity. Involved in detoxification of zinc ion; intracellular zinc ion homeostasis; and zinc ion import across plasma membrane. Located in basolateral plasma membrane. Is expressed in adult Malpighian tubule; adult head; and embryonic/larval Malpighian tubule. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2 and myopia. Orthologous to human SLC39A14 (solute carrier family 39 member 14) and SLC39A5 (solute carrier family 39 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14992289..14997983)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14985389..14990917)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

ZIP10 is found in the Malpighian tubules and has a role in zinc transport.
Title: Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn(2+) transporter.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in detoxification of zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain