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Brd Bearded [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39620, updated on 4-Jan-2025

Summary

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Official Symbol
Brdprovided by FlyBase
Official Full Name
Beardedprovided by FlyBase
Primary source
FLYBASE:FBgn0000216
Locus tag
Dmel_CG3096
See related
AllianceGenome:FB:FBgn0000216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bearded; brd; Brd-C; CG3096; DmelCG3096; Dmel\CG3096
Summary
Enables ubiquitin protein ligase binding activity. Involved in cell fate specification. Is expressed in several structures, including eye disc morphogenetic furrow; hindgut proper primordium; imaginal disc; proneural cluster; and wing. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Brd in Genome Data Viewer
Location:
71A4-71A4; 3-42 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14972667..14973198)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14965767..14966298)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45978 Neighboring gene Twin of m4 Neighboring gene long non-coding RNA:marge Neighboring gene ocho

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. minidiscs encodes a putative amino acid transporter subunit required non-autonomously for imaginal cell proliferation. Martin JF, et al. Mech Dev, 2000 Apr. PMID 10727855
  2. Drop out: a third chromosome maternal-effect locus required for formation of the Drosophila cellular blastoderm. Galewsky S, et al. Mol Reprod Dev, 1992 Aug. PMID 1497881
  3. Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Bang AG, et al. Development, 1991 Jan. PMID 2015800
  4. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Seppo A, et al. Development, 2003 Apr. PMID 12588858
  5. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression. Lai EC, et al. Development, 1997 Dec. PMID 9428421

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Neuralized (Neur) regulates collective apical constriction and furrow formation, and the Bearded (Brd) proteins antagonize maternal Neur and lower medial-apical contractility in the ectoderm.
    Title: Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila.
  2. inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta
    Title: Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta.
  3. inhibition of Neur by Brd proteins is important for precise spatial regulation of Dl signaling
    Title: Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
bearded
Names
Brd-PA
CG3096-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14972667..14973198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057541.5 → NP_476889.1  bearded [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476889.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16528, Q5G1W4
    Related
    FBpp0075374
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16528 O16528
Q5G1W4 Q5G1W4
Q5G1X9 Q5G1X9
Q5G1Y7 Q5G1Y7

Gene LinkOut

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