mop myopic [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mopprovided by FlyBase
Official Full Name: myopicprovided by FlyBase
Primary source: FLYBASE:FBgn0036448
Locus tag: Dmel_CG9311
See related: AllianceGenome:FB:FBgn0036448
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9311; Dmel\CG9311; Mop; MOP; sfv
Summary: Involved in several processes, including endosomal transport; follicle cell of egg chamber-cell adhesion; and positive regulation of cell communication. Located in endosome. Is active in neuromuscular junction. Is expressed in adult head. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 70F4-70F5; 3-42 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14769341..14776129, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14762441..14769229, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

endocytosis of Wg requires a specific endocytosis regulator (Mop) implying that Wg signaling is mediated by special endocytic pathways.
Title: The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless.
Expression of the Rab4 dominant-negative mutant leads to border cell dissociation and suppression of Mop-induced wing-blade adhesion defects, suggesting a critical role of Rab4 in Mop-mediated signaling
Title: The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration.
show that the endosomal proteins Myopic (Mop) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are required for the activation of the Toll signaling pathway.
Title: Endocytic pathway is required for Drosophila Toll innate immune signaling.
Data suggest that Myopic (CG9311)promotes EGFR signaling by mediating its progression through the endocytic pathway
Title: Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables phosphatase activity	IKR Inferred from Key Residues more info	PubMed
NOT enables protein tyrosine phosphatase activity	IKR Inferred from Key Residues more info	PubMed

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myopic

Names: CG9311-PA; mop-PA; slaughterhouse-five

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14769341..14776129 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140465.3 → NP_648722.2 myopic [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648722.2

Status: REVIEWED

UniProtKB/TrEMBL

Q960G3, Q9VUH6

Related

FBpp0075450

Conserved Domains (6) summary

cd09234
Location:368 → 702

V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd09239
Location:2 → 363

BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains

cd00047
Location:1559 → 1745

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam09606
Location:808 → 1246

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam00102
Location:1558 → 1788

Y_phosphatase; Protein-tyrosine phosphatase

pfam13949
Location:421 → 699

ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV