U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mgat4a alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39608, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Mgat4aprovided by FlyBase
Official Full Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase aprovided by FlyBase
Primary source
FLYBASE:FBgn0036446
Locus tag
Dmel_CG9384
See related
AllianceGenome:FB:FBgn0036446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9384; Dmel\CG9384; dMGAT4-1; MGAT
Summary
Predicted to enable alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be active in Golgi stack; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult head. Orthologous to several human genes including MGAT4A (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A) and MGAT4B (alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mgat4a in Genome Data Viewer
Location:
70F4-70F4; 3-42 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14762028..14767703)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14755128..14760803)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Trithorax-like Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b Neighboring gene myopic

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. Baas S, et al. Development, 2011 Feb. PMID 21205799, Free PMC Article
  2. Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Miura GI, et al. Development, 2008 Jun. PMID 18434417, Free PMC Article
  3. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
  4. Genes and biological processes controlled by the Drosophila FOXA orthologue Fork head. Liu Y, et al. Insect Mol Biol, 2008 Apr. PMID 18353099
  5. A journey into the world of insect lipid metabolism. Toprak U, et al. Arch Insect Biochem Physiol, 2020 Jun. PMID 32335968

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase a
Names
CG9384-PA
CG9384-PB
Mgat4a-PA
Mgat4a-PB
NP_001261847.1
NP_648720.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14762028..14767703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274918.1 → NP_001261847.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase a, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261847.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYS6, Q9VUH4
    Conserved Domains (1) summary
    pfam04666
    Location:129 → 412
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  2. NM_140463.4 → NP_648720.3  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase a, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648720.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYS6, Q9VUH4
    Related
    FBpp0075440
    Conserved Domains (1) summary
    pfam04666
    Location:129 → 412
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYS6 Q8SYS6
Q9VUH4 Q9VUH4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous