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shd shade [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39592, updated on 4-Jan-2025

Summary

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Official Symbol
shdprovided by FlyBase
Official Full Name
shadeprovided by FlyBase
Primary source
FLYBASE:FBgn0003388
Locus tag
Dmel_CG13478
See related
AllianceGenome:FB:FBgn0003388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
314a1; CG13478; cyp314a1; Cyp314a1; CYP314A1; Dmel\CG13478; Shade; Shd
Summary
Enables ecdysone 20-monooxygenase activity. Involved in several processes, including embryonic development via the syncytial blastoderm; instar larval or pupal development; and oogenesis. Located in mitochondrion. Is expressed in several structures, including dorsal epidermis primordium; embryonic/larval fat body; embryonic/larval midgut; epidermis; and gastric caecum. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See shd in Genome Data Viewer
Location:
70E4-70E4; 3-42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14614458..14622205)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14607558..14615305)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene HGTX Neighboring gene uncharacterized protein Neighboring gene RecQ5 helicase Neighboring gene dally-like Neighboring gene long non-coding RNA:CR45888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Blimp-1 Mediates Tracheal Lumen Maturation in Drosophila melanogaster. Öztürk-Çolak A, et al. Genetics, 2018 Oct. PMID 30082278, Free PMC Article
  2. Steroid signaling in mature follicles is important for Drosophila ovulation. Knapp E, et al. Proc Natl Acad Sci U S A, 2017 Jan 24. PMID 28069934, Free PMC Article
  3. Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development. Russo A, et al. Dev Biol, 2019 Nov 1. PMID 31283922
  4. Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila. Rauschenbach IY, et al. J Comp Physiol B, 2008 Jan. PMID 17703313
  5. A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. Akagi K, et al. Development, 2016 Jul 1. PMID 27226323

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
    Title: A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster.
  2. Examine role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila.
    Title: Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ecdysone 20-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysteroid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ecdysteroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in growth of a germarium-derived egg chamber IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midgut development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pupation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
shade
Names
CG13478-PB
CG13478-PC
CG13478-PD
cytochrome P450
ecdysone 20-monooxygenase
shd-PB
shd-PC
shd-PD
NP_001261843.1
NP_648709.2
NP_996074.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14614458..14622205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274914.1 → NP_001261843.1  shade, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T483, Q9VUF8
    UniProtKB/TrEMBL
    M9PI59
    Conserved Domains (1) summary
    cl12078
    Location:63 → 528
    p450; Cytochrome P450

  2. NM_206352.2 → NP_996074.1  shade, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996074.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T483, Q9VUF8
    UniProtKB/TrEMBL
    M9PI59
    Conserved Domains (1) summary
    cl12078
    Location:63 → 528
    p450; Cytochrome P450

  3. NM_140452.2 → NP_648709.2  shade, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648709.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VUF8
    Related
    FBpp0293243, FBtr0304700
    Conserved Domains (1) summary
    cl12078
    Location:6 → 421
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI59 M9PI59
Q9VUF8.3 Q9VUF8

Gene LinkOut

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