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stwl stonewall [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39581, updated on 4-Jan-2025

Summary

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Official Symbol
stwlprovided by FlyBase
Official Full Name
stonewallprovided by FlyBase
Primary source
FLYBASE:FBgn0003459
Locus tag
Dmel_CG3836
See related
AllianceGenome:FB:FBgn0003459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
84; CG3836; Dmel\CG3836; fs(3)02024; snw; Stwl
Summary
Predicted to enable DNA binding activity. Involved in several processes, including DNA protection; female germ-line stem cell population maintenance; and larval lymph gland hemopoiesis. Located in nucleolus. Colocalizes with polytene chromosome. Is expressed in several structures, including adult brain cell body rind; adult heart; epithelial cell; germarium region 1; and germline cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See stwl in Genome Data Viewer
Location:
70D6-70D7; 3-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14402930..14409939, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14396030..14403039, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45233 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46032 Neighboring gene uncharacterized protein Neighboring gene big bang

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations of stonewall disrupt the maintenance of female germline stem cells in Drosophila melanogaster. Akiyama T. Dev Growth Differ, 2002 Apr. PMID 11940096
  2. Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis. Kotb NM, et al. Genes Dev, 2024 Jun 25. PMID 38866556, Free PMC Article
  3. Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication. Yi X, et al. Mol Biol Cell, 2009 Feb. PMID 19056684, Free PMC Article
  4. Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila. Jaklevic B, et al. Genetics, 2006 Dec. PMID 17028317, Free PMC Article
  5. A nuclear architecture screen in Drosophila identifies Stonewall as a link between chromatin position at the nuclear periphery and germline stem cell fate. Chavan A, et al. Genes Dev, 2024 Jun 25. PMID 38866555, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.
    Title: Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.
  2. brwl and stwl likely share a common MADF-BESS ancestor and they are expressed in overlapping spatiotemporal domains to ensure robust development of the female germline.
    Title: Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila.
  3. The identification of stonewall (stwl) as a novel hydroxyurea-hypersensitive mutant, is reported.
    Title: Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.
  4. stwl(UY823) overexpression, like overexpression of the wild-type gene, activated G1/S transition and apoptosis
    Title: The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers.
  5. Stwl-dependent transcriptional repression does not target bam, but rather Stwl represses the expression of many genes, including those that may be targeted by Nanos and Pumilio translational inhibition.
    Title: Stonewalling Drosophila stem cell differentiation by epigenetic controls.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c14408255-14408198 mobile_element_type = transposon:INE-1{}3249

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA protection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval lymph gland hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stonewall
Names
CG3836-PA
CG3836-PB
CG3836-PC
STONEWALL
alpha transcript
stwl-PA
stwl-PB
stwl-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14402930..14409939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274910.1 → NP_001261839.1  stonewall, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24156, Q9VUE5
    Conserved Domains (2) summary
    smart00595
    Location:11 → 98
    MADF; subfamily of SANT domain
    pfam02944
    Location:604 → 637
    BESS; BESS motif

  2. NM_079344.3 → NP_524068.2  stonewall, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524068.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24156, Q9VUE5
    Related
    FBpp0075471
    Conserved Domains (2) summary
    smart00595
    Location:11 → 98
    MADF; subfamily of SANT domain
    pfam02944
    Location:604 → 637
    BESS; BESS motif

  3. NM_001274909.1 → NP_001261838.1  stonewall, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A075BJG7, A0A075BLW2, M9PI58
    Conserved Domains (3) summary
    pfam02944
    Location:566 → 599
    BESS; BESS motif
    cl01319
    Location:132 → 203
    HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain
    cl23759
    Location:13 → 60
    GT1; GT1, myb-like, SANT family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI58 M9PI58
Q24156 Q24156
Q9VUE5 Q9VUE5

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