U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CtsK1 Cathepsin K1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39547, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CtsK1provided by FlyBase
Official Full Name
Cathepsin K1provided by FlyBase
Primary source
FLYBASE:FBgn0250848
Locus tag
Dmel_CG8947
See related
AllianceGenome:FB:FBgn0250848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
26-29-p; 26/29kD-proteinase; anon-SAGE:Wang-123; CG8947; Cts6; CTSK; Dmel\CG8947; l(3)s3635
Summary
Enables cysteine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade and zymogen activation. Is active in extracellular space. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CtsK1 in Genome Data Viewer
Location:
70C10-70C10; 3-41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13994231..13996571)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13987331..13989671)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nitrogen permease regulator-like 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two subunits of the insect 26/29-kDa proteinase are probably derived from a common precursor protein. Fujimoto Y, et al. J Biochem, 1999 Mar. PMID 10050046
  2. Cp1/cathepsin L is required for autolysosomal clearance in Drosophila. Xu T, et al. Autophagy, 2021 Oct. PMID 33112206, Free PMC Article
  3. Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar S, et al. J Biomol Struct Dyn, 2013 Dec. PMID 23256878
  4. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Kawasaki H, et al. Gene, 2017 May 30. PMID 28286087
  5. The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway. Issa N, et al. Mol Cell, 2018 Feb 15. PMID 29452635, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zymogen activation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cathepsin K1
Names
26,29kDa proteinase
26-29 kD-proteinase
26-29-protease
26-29kD-proteinase
26-29kDa proteinase
26-29kd prot
CG8947-PA
CtsK1-PA
anon-SAGE:Wang-123
cathepsin K
NP_620470.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13994231..13996571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138985.3 → NP_620470.1  cathepsin K1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_620470.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3U6
    Related
    FBpp0075508
    Conserved Domains (2) summary
    smart00848
    Location:245 → 300
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:331 → 547
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3U6 Q9V3U6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools