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dysc dyschronic [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39533, updated on 9-Dec-2024

Summary

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Official Symbol
dyscprovided by FlyBase
Official Full Name
dyschronicprovided by FlyBase
Primary source
FLYBASE:FBgn0264006
Locus tag
Dmel_CG43749
See related
AllianceGenome:FB:FBgn0264006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-AE003536.1; CG17368; CG32131; CG32132; CG34400; CG43749; CG8760; Dmel\CG43749; Dm_3L:69335; DYSC
Old locus tag
CG17368; CG32131; CG8760; Dmel_CG17368; Dmel_CG32131; Dmel_CG32132; Dmel_CG34400; Dmel_CG8760
Summary
Involved in several processes, including locomotor rhythm; muscle cell cellular homeostasis; and neuron development. Located in synapse. Is expressed in several structures, including adult brain; adult head; adult mushroom body; adult pacemaker neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Usher syndrome type 2D; autosomal recessive nonsyndromic deafness 31; and sensorineural hearing loss. Orthologous to human WHRN (whirlin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See dysc in Genome Data Viewer
Location:
70C5-70C5; 3-41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13867414..13903236, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13860514..13896336, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Hemolectin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ral guanine nucleotide dissociation stimulator-like Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetics, pathogenesis and therapeutic developments for Usher syndrome type 2. Stemerdink M, et al. Hum Genet, 2022 Apr. PMID 34331125
  2. Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia. Kratschmer P, et al. Mov Disord, 2021 May. PMID 33449381, Free PMC Article
  3. Dissecting the Genetic Basis of Variation in Drosophila Sleep Using a Multiparental QTL Mapping Resource. Smith BR, et al. Genes (Basel), 2020 Mar 11. PMID 32168738, Free PMC Article
  4. Antagonistic Regulation of Circadian Output and Synaptic Development by JETLAG and the DYSCHRONIC-SLOWPOKE Complex. Lamaze A, et al. iScience, 2020 Feb 21. PMID 32058958, Free PMC Article
  5. Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic. Jepson JE, et al. Development, 2014 Dec. PMID 25359729, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dyschronic regulates synaptic development and function at the neuromuscular junction.
    Title: Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c13896438-13896388 mobile_element_type = transposon:INE-1{}2782

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of stereocilia ankle link complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stereocilium tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dyschronic
Names
CG43749-PC
CG43749-PE
CG43749-PF
CG43749-PG
CG43749-PH
CG43749-PI
CG43749-PJ
dysc-PC
dysc-PE
dysc-PF
dysc-PG
dysc-PH
dysc-PI
dysc-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13867414..13903236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274884.2 → NP_001261813.1  dyschronic, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261813.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI53
    Conserved Domains (2) summary
    cd00992
    Location:294 → 376
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:569 → 649
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

  2. NM_001144475.3 → NP_001137947.1  dyschronic, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137947.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z048
    Conserved Domains (2) summary
    cd00992
    Location:294 → 380
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:573 → 653
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

  3. NM_001274883.2 → NP_001261812.1  dyschronic, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFF3
    Conserved Domains (2) summary
    cd00992
    Location:294 → 380
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:573 → 653
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

  4. NM_001274882.2 → NP_001261811.1  dyschronic, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261811.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFJ0
    Conserved Domains (2) summary
    cd00992
    Location:294 → 380
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:573 → 653
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

  5. NM_140411.5 → NP_648668.3  dyschronic, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648668.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VU98
    Conserved Domains (2) summary
    cd00992
    Location:294 → 380
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:573 → 653
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

  6. NM_001274881.2 → NP_001261810.1  dyschronic, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261810.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF56
    Conserved Domains (2) summary
    cd00992
    Location:294 → 380
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:573 → 653
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

  7. NM_001144474.3 → NP_001137946.1  dyschronic, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137946.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z049
    Conserved Domains (2) summary
    cd00992
    Location:294 → 380
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd07357
    Location:573 → 653
    HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z048 B7Z048
B7Z049 B7Z049
M9PF56 M9PF56
M9PFF3 M9PFF3
M9PFJ0 M9PFJ0
M9PI53 M9PI53
Q9VU98 Q9VU98

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