Ptp69D Protein tyrosine phosphatase 69D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptp69Dprovided by FlyBase
Official Full Name: Protein tyrosine phosphatase 69Dprovided by FlyBase
Primary source: FLYBASE:FBgn0014007
Locus tag: Dmel_CG10975
See related: AllianceGenome:FB:FBgn0014007
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 69D; CG10975; CT30751; Dmel\CG10975; DPTP; dptp69d; dptp69D; Dptp69D; DPTP69D; Ptp; ptp69; ptp69d; ptp69D; Ptp69d; PTP69D; PTPase; R-PTP 69D; rptp69d; RPtp69D
Summary: Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in neuron development. Located in axon and cell surface. Is expressed in several structures, including CNS glial cell; adult brain cell body rind; adult head; brain; and central brain primordium. Human ortholog(s) of this gene implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 69D6-69E1; 3-39 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12734945..12741568)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12728045..12734668)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein tyrosine phosphatase 69D is a substrate of protein O-mannosyltransferases 1-2 that is required for the wiring of sensory axons in Drosophila.
Title: Protein tyrosine phosphatase 69D is a substrate of protein O-mannosyltransferases 1-2 that is required for the wiring of sensory axons in Drosophila.
The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.
Title: The RNA-binding protein Musashi controls axon compartment-specific synaptic connectivity through ptp69D mRNA poly(A)-tailing.
The authors found that the depth of the final layer of stable photoreceptor axon termination relied primarily on the cumulative amount of LAR and Ptp69D cytoplasmic activity, while specific features of their ectodomains contribute to the choice between two synaptic layers, M3 and M6, in the medulla.
Title: Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system.
the role of Slit and Robo receptors in wiring Drosophila higher-order brain circuits and identified differences in the cellular and molecular mechanisms of Robo/Slit function, was investigated.
Title: Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.
The single-growth-cone analysis suggests that Slit and RPTP69D are unlikely to influence axon sprouting, or branch initiation of mechanosensory-neurons, but rather control the selective consolidation and directed extension of midline-crossing axon branches.
Title: Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1.
Mutations in the first Ig and catalytic domains disrupt synaptic terminal growth. PTP69D role in terminal growth is mechanistically distinct from axon targeting.
Title: Structure-function analyses of tyrosine phosphatase PTP69D in giant fiber synapse formation of Drosophila.
Ptp69D is expressed only on the innermost core fibers during development of the larval mushroom body; it regulates segregation of young axons into a single core bundle.
Title: Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.
indicate that mutations in Ptp69D resulting in axon guidance defects and lethality significantly compromise catalytic activity
Title: Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects.
DPTP69D has a role in axon outgrowth in Drosophila
Title: The neural receptor protein tyrosine phosphatase DPTP69D is required during periods of axon outgrowth in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defasciculation of motor neuron axon	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defasciculation of motor neuron axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fasciculation of sensory neuron axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic target inhibition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: protein tyrosine phosphatase 69D

Names: CG10975-PA; CG10975-PB; Ptp69D-PA; Ptp69D-PB; protein tyrosine phosphatase PTP69D

NP_524048.2

EC 3.1.3.-

EC 3.1.3.48

NP_788502.1

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12734945..12741568

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079324.3 → NP_524048.2 protein tyrosine phosphatase 69D, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524048.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P16620, Q8IGY3, Q9VU03

Related

FBpp0075645

Conserved Domains (7) summary

cd00096
Location:150 → 221

Ig; Immunoglobulin domain

PHA02694
Location:1121 → 1206

PHA02694; hypothetical protein; Provisional

smart00194
Location:892 → 1155

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:139 → 233

IG_like; Immunoglobulin like

cd00047
Location:920 → 1155

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:339 → 432

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:237 → 321

fn3; Fibronectin type III domain
NM_176324.2 → NP_788502.1 protein tyrosine phosphatase 69D, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788502.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P16620

Related

FBpp0075646

Conserved Domains (7) summary

cd00096
Location:150 → 221

Ig; Immunoglobulin domain

PHA02694
Location:1120 → 1205

PHA02694; hypothetical protein; Provisional

smart00194
Location:891 → 1154

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00410
Location:139 → 233

IG_like; Immunoglobulin like

cd00047
Location:919 → 1154

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:339 → 432

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:237 → 321

fn3; Fibronectin type III domain