Tsf2 Transferrin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tsf2provided by FlyBase
Official Full Name: Transferrin 2provided by FlyBase
Primary source: FLYBASE:FBgn0036299
Locus tag: Dmel_CG10620
See related: AllianceGenome:FB:FBgn0036299
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10620; Dmel\CG10620; mtf; Mtf; MTf; tsf2
Summary: Enables iron ion binding activity. Involved in septate junction assembly. Located in endosome; plasma membrane; and septate junction. Is expressed in several structures, including adult brain; adult head; clypeo-labral primordium; epithelium; and gut section. Used to study chromosome 3q29 microdeletion syndrome. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); atransferrinemia; carcinoma (multiple); glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to several human genes including MELTF (melanotransferrin) and TF (transferrin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12530436..12533724, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12523536..12526824, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

functional dissection of MTf in epithelial junction assembly and morphogenesis
Title: Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in septate junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IPI Inferred from Physical Interaction more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IPI Inferred from Physical Interaction more info	PubMed
located_in septate junction	IPI Inferred from Physical Interaction more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain