nst nesthocker [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nstprovided by FlyBase
Official Full Name: nesthockerprovided by FlyBase
Primary source: FLYBASE:FBgn0036298
Locus tag: Dmel_CG10627
See related: AllianceGenome:FB:FBgn0036298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10627; Dmel\CG10627; DPgm3; Pgm3; PGM3
Summary: Predicted to enable phosphoacetylglucosamine mutase activity. Involved in several processes, including UDP-N-acetylglucosamine biosynthetic process; positive regulation of fibroblast growth factor receptor signaling pathway; and trachea development. Predicted to be located in cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; mesoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12527215..12530171, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12520315..12523271, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoacetylglucosamine mutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoacetylglucosamine mutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

NP_648588.1

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The following sections contain reference sequences that belong to a specific genome build. Explain