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ver verrocchio [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39432, updated on 9-Dec-2024

Summary

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Official Symbol
verprovided by FlyBase
Official Full Name
verrocchioprovided by FlyBase
Primary source
FLYBASE:FBgn0262524
Locus tag
Dmel_CG14121
See related
AllianceGenome:FB:FBgn0262524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1479/10; anon-WO0172774.86; anon-WO0172774.87; anon-WO0172774.89; CG14121; Dmel\CG14121; l(3)S147910; Ver
Summary
Contributes to single-stranded telomeric DNA binding activity. Involved in telomere capping. Part of telomere cap complex. Is expressed in wing disc. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ver in Genome Data Viewer
Location:
69C4-69C4; 3-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12523987..12525150)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12517087..12518250)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sticky Neighboring gene long non-coding RNA:CR45168 Neighboring gene trailer hitch Neighboring gene Gcn5 acetyltransferase Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene nesthocker Neighboring gene Transferrin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein. Cicconi A, et al. Methods Mol Biol, 2021. PMID 33847963
  2. On the origin of the eukaryotic chromosome: the role of noncanonical DNA structures in telomere evolution. Garavís M, et al. Genome Biol Evol, 2013. PMID 23699225, Free PMC Article
  3. Transposon control mechanisms in telomere biology. Kordyukova M, et al. Curr Opin Genet Dev, 2018 Apr. PMID 29571043
  4. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Raffa GD, et al. Genes Dev, 2010 Aug 1. PMID 20679394, Free PMC Article
  5. If the cap fits, wear it: an overview of telomeric structures over evolution. Fulcher N, et al. Cell Mol Life Sci, 2014 Mar. PMID 24042202, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evolutionary mode for the functional preservation of fast-evolving Drosophila telomere capping proteins.
    Title: Evolutionary mode for the functional preservation of fast-evolving Drosophila telomere capping proteins.
  2. Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein.
    Title: Atomic Force Microscopy Reveals that the Drosophila Telomere-Capping Protein Verrocchio Is a Single-Stranded DNA-Binding Protein.
  3. Ver binds telomeric single-stranded DNA
    Title: The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.
  4. Here we discover a novel protein, Tea, that is specifically enriched at telomeres to prevent telomere fusion. We also identify a complex consisting of Tea and two known capping proteins, Ver and Moi. The Moi-Tea-Ver (MTV) complex purified in vitro binds and protects ssDNA in a sequence-independent manner.
    Title: MTV, an ssDNA Protecting Complex Essential for Transposon-Based Telomere Maintenance in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in telomere capping IC
Inferred by Curator
more info
 PubMed 
involved_in telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of telomere cap complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
verrocchio
Names
CG14121-PA
CG14121-PB
lethal (3) S147910
ver-PA
ver-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12523987..12525150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140330.2 → NP_648587.1  verrocchio, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648587.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTZ2
    Related
    FBpp0075692

  2. NM_001274848.1 → NP_001261777.1  verrocchio, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261777.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTZ2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTZ2 Q9VTZ2

Gene LinkOut

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