sox7 SRY-box transcription factor 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sox7provided by ZNC
Official Full Name: SRY-box transcription factor 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-040109-4
See related: Ensembl:ENSDARG00000030125 AllianceGenome:ZFIN:ZDB-GENE-040109-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within artery development and vasculogenesis. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; hindbrain; intermediate cell mass of mesoderm; and mesoderm. Orthologous to human SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (19075127..19078424)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (19167280..19178841)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox7 levels are crucial in arterial specification in conjunction with hey2 and efnb2 function, with mutants in all three genes displaying shunt formation and an arterial block.
Title: Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.
Sox7/18 factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
Title: SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
Sox7 and Sox18-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
Title: Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish.
Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression.
Title: Zebrafish Sox7 and Sox18 function together to control arterial-venous identity.
Sox7 and sox18 play redundant but collectively essential roles in the establishment of proper arteriovenous identity in zebrafish.
Title: Sox18 and Sox7 play redundant roles in vascular development.
Sox7 and sox18 are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta.
Title: Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within artery development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor SOX-7

Names: SRY (sex determining region Y)-box 7; SRY-box containing gene 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080750.2 → NP_001074219.1 transcription factor SOX-7

See identical proteins and their annotated locations for NP_001074219.1

Status: PROVISIONAL

Source sequence(s)

AY423014

UniProtKB/TrEMBL

A0A2R8Q0J9, F6NS93, Q6TEN5

Related

ENSDARP00000147155.1, ENSDART00000181529.1

Conserved Domains (2) summary

cd01388
Location:42 → 113

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam12067
Location:174 → 388

Sox_C_TAD; Sox C-terminal transactivation domain