pum1 pumilio RNA-binding family member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pum1provided by ZNC
Official Full Name: pumilio RNA-binding family member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2074
See related: Ensembl:ENSDARG00000099256 AllianceGenome:ZFIN:ZDB-GENE-030131-2074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb96a03; pumilio1; zgc:63671; wu:fb96a03; wu:fb96a08; si:ch211-285e16.1
Summary: Enables mRNA binding activity. Involved in pole plasm mRNA localization. Predicted to be active in cytosol. Is expressed in oocyte stage IV and ovary. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Orthologous to human PUM1 (pumilio RNA binding family member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (43037657..43089455)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (43468220..43517760)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pum1 phosphorylation in the early period of oocyte maturation is one of the key processes for promoting the disassembly of cyclin B1 RNA granules and translational activation of target mRNA.
Title: Pumilio1 phosphorylation precedes translational activation of its target mRNA in zebrafish oocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

AI588093 (e-PCR)
- UniSTS:206208

fb96a03 (e-PCR), detects polymorphism
- UniSTS:189098

fb96a08 (e-PCR), detects polymorphism
- UniSTS:189100

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pole plasm mRNA localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pumilio homolog 1

Names: pumilio homolog 1 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277119.2 → NP_001264048.1 pumilio homolog 1

Status: VALIDATED

Source sequence(s)

AB841266, BC055197

UniProtKB/TrEMBL

A0A0R4IWL6, A0A8M1NZX5, S6B5C2

Related

ENSDARP00000140793.2, ENSDART00000168263.2

Conserved Domains (1) summary

cd07920
Location:807 → 1130

Pumilio; Pumilio-family RNA binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

43037657..43089455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_201201.1: Suppressed sequence

Description

NM_201201.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.