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rem1 RAS (RAD and GEM)-like GTP-binding 1 [ Danio rerio (zebrafish) ]

Gene ID: 394149, updated on 9-Dec-2024

Summary

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Official Symbol
rem1provided by ZNC
Official Full Name
RAS (RAD and GEM)-like GTP-binding 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040317-1
See related
Ensembl:ENSDARG00000020544 AllianceGenome:ZFIN:ZDB-GENE-040317-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GEM; rem; horizin; zgc:56144; SI:zK76P14.3
Summary
Enables calcium channel regulator activity. Predicted to act upstream of or within negative regulation of high voltage-gated calcium channel activity. Predicted to be active in plasma membrane. Is expressed in nervous system; neural tube; segmental plate; and somite. Orthologous to human REM1 (RRAD and GEM like GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See rem1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24311390..24331318)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24076252..24093703)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene purine nucleoside phosphorylase 4a Neighboring gene si:dkey-76p14.2 Neighboring gene si:ch211-15p9.2 Neighboring gene RNA binding motif protein 39a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. Puhl HL 3rd, et al. PLoS One, 2014. PMID 24992013, Free PMC Article
  2. pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless. Kimura T, et al. G3 (Bethesda), 2017 Apr 3. PMID 28258112, Free PMC Article
  3. Tbx16 regulates hox gene activation in mesodermal progenitor cells. Payumo AY, et al. Nat Chem Biol, 2016 Sep. PMID 27376691, Free PMC Article
  4. Gene expression profiling of zebrafish embryonic retina. Leung YF, et al. Zebrafish, 2005. PMID 18248185
  5. Unifying developmental programs for embryonic and postembryonic neurogenesis in the zebrafish retina. Xu B, et al. Development, 2020 Jun 19. PMID 32467236

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56144

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTP-binding protein REM 1
Names
rad and gem related GTP binding protein 1
NP_957468.1
XP_009304297.1
XP_068080235.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201174.1 → NP_957468.1  GTP-binding protein REM 1

    See identical proteins and their annotated locations for NP_957468.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045943
    UniProtKB/TrEMBL
    A0A2R8QI14, B2GS53, Q7ZVA2
    Related
    ENSDARP00000005231.5, ENSDART00000017599.8
    Conserved Domains (2) summary
    smart00010
    Location:77 → 244
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:77 → 298
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    24311390..24331318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224134.1 → XP_068080235.1  GTP-binding protein REM 1 isoform X1

  2. XM_009306022.4 → XP_009304297.1  GTP-binding protein REM 1 isoform X2

    See identical proteins and their annotated locations for XP_009304297.1

    UniProtKB/TrEMBL
    A0A2R8QI14, B2GS53, Q7ZVA2
    Conserved Domains (2) summary
    smart00010
    Location:77 → 244
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:77 → 298
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
Nucleotide Protein Strain
Heading Accession and Version

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