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vrk2 VRK serine/threonine kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 394145, updated on 4-Jan-2025

Summary

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Official Symbol
vrk2provided by ZNC
Official Full Name
VRK serine/threonine kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1046
See related
Ensembl:ENSDARG00000021547 AllianceGenome:ZFIN:ZDB-GENE-040426-1046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vrk; zgc:56483
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within aggressive behavior and social behavior. Predicted to be located in membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK2 (VRK serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See vrk2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (26780004..26799235, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (26649550..26668785, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487401 Neighboring gene si:rp71-1h3.1 Neighboring gene FA complementation group L Neighboring gene coiled-coil domain containing 85A Neighboring gene heme-binding protein soul2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Behavioral and neurological effects of Vrk1 deficiency in zebrafish. Carrasco Apolinario ME, et al. Biochem Biophys Res Commun, 2023 Oct 1. PMID 37429068
  2. Vrk2 deficiency elicits aggressive behavior in female zebrafish. Umeda R, et al. Genes Cells, 2022 Apr. PMID 35094457
  3. Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. Bagheri H, et al. JCI Insight, 2016 Mar 17. PMID 27699255, Free PMC Article
  4. The Fanconi anemia gene network is conserved from zebrafish to human. Titus TA, et al. Gene, 2006 Apr 26. PMID 16515849
  5. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vrk2 deficiency elicits aggressive behavior in female zebrafish.
    Title: Vrk2 deficiency elicits aggressive behavior in female zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC56483

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aggressive behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase VRK2
Names
vaccinia related kinase 2
NP_957464.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201170.2 → NP_957464.2  serine/threonine-protein kinase VRK2

    Status: VALIDATED

    Source sequence(s)
    CR354594, EH589503
    UniProtKB/TrEMBL
    A0A8M1PE59, A0A8M6Z1N2, B8JHS7
    Related
    ENSDARP00000038349.7, ENSDART00000036419.9
    Conserved Domains (2) summary
    COG0515
    Location:25 → 406
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14123
    Location:13 → 313
    STKc_VRK2; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    26780004..26799235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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