pelo pelota mRNA surveillance and ribosome rescue factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: peloprovided by ZNC
Official Full Name: pelota mRNA surveillance and ribosome rescue factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1074
See related: Ensembl:ENSDARG00000055477 AllianceGenome:ZFIN:ZDB-GENE-040426-1074
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ITGA1; zgc:56550; wu:fa12c12; wu:fb97f07
Summary: Predicted to enable ribosome binding activity. Predicted to be involved in nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; and rescue of stalled ribosome. Predicted to act upstream of or within RNA surveillance; cell division; and nuclear-transcribed mRNA catabolic process, non-stop decay. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytoplasm. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (13189213..13205562, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (13150910..13167259, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA surveillance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in nonfunctional rRNA decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, non-stop decay	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Dom34-Hbs1 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: protein pelota homolog

Names: pelota homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201136.1 → NP_957430.1 protein pelota homolog

See identical proteins and their annotated locations for NP_957430.1

Status: PROVISIONAL

Source sequence(s)

BC049484

UniProtKB/Swiss-Prot

Q7ZWC4

Related

ENSDARP00000072295.4, ENSDART00000077829.6

Conserved Domains (4) summary

COG1537
Location:1 → 370

PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]

pfam03463
Location:1 → 128

eRF1_1; eRF1 domain 1

pfam03464
Location:136 → 268

eRF1_2; eRF1 domain 2

pfam03465
Location:271 → 370

eRF1_3; eRF1 domain 3