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sardh sarcosine dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 394103, updated on 9-Dec-2024

Summary

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Official Symbol
sardhprovided by ZNC
Official Full Name
sarcosine dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-996
See related
Ensembl:ENSDARG00000058102 AllianceGenome:ZFIN:ZDB-GENE-040426-996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56363
Summary
Predicted to enable sarcosine dehydrogenase activity. Predicted to be involved in sarcosine catabolic process. Predicted to be active in mitochondrial matrix. Is expressed in alar plate midbrain region; digestive system; myotome; nervous system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See sardh in Genome Data Viewer
Location:
chromosome: 10
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (10386571..10561822)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (10428312..10603584)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene microRNA 219-1 Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene dopamine beta-hydroxylase (dopamine beta-monooxygenase) Neighboring gene family with sequence similarity 163 member B, genome duplicate a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. COMICS: Cartoon Visualization of Omics Data in Spatial Context Using Anatomical Ontologies. Travin D, et al. J Proteome Res, 2018 Jan 5. PMID 29083911, Free PMC Article
  2. The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish. van der Ven LTM, et al. Toxicol Appl Pharmacol, 2020 Nov 15. PMID 32979392
  3. Proteomics of early zebrafish embryos. Link V, et al. BMC Dev Biol, 2006 Jan 13. PMID 16412219, Free PMC Article
  4. Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes. Huang Y, et al. BMC Genomics, 2015 Jun 4. PMID 26040990, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56363

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sarcosine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sarcosine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sarcosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sarcosine dehydrogenase, mitochondrial
NP_001313615.1
XP_005155653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326686.1 → NP_001313615.1  sarcosine dehydrogenase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AL935290, BX323065, BX537125
    UniProtKB/TrEMBL
    A0A8M1P859, F1Q5K3
    Related
    ENSDARP00000154120.1, ENSDART00000193875.1
    Conserved Domains (5) summary
    COG0404
    Location:476 → 913
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:60 → 444
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:486 → 795
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:804 → 897
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:427 → 481
    FAO_M; FAD dependent oxidoreductase central domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    10386571..10561822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155596.5 → XP_005155653.1  sarcosine dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005155653.1

    UniProtKB/TrEMBL
    A0A8M1P859, F1Q5K3
    Related
    ENSDARP00000148230.1, ENSDART00000189799.1
    Conserved Domains (5) summary
    COG0404
    Location:476 → 913
    GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
    COG0665
    Location:60 → 444
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    pfam01571
    Location:486 → 795
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:804 → 897
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
    pfam16350
    Location:427 → 481
    FAO_M; FAD dependent oxidoreductase central domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394772.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    114903..270345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201128.1: Suppressed sequence

    Description
    NM_201128.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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