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wasf2 WASP family member 2 [ Danio rerio (zebrafish) ]

Gene ID: 394056, updated on 9-Dec-2024

Summary

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Official Symbol
wasf2provided by ZNC
Official Full Name
WASP family member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-865
See related
Ensembl:ENSDARG00000024209 AllianceGenome:ZFIN:ZDB-GENE-040426-865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56010
Summary
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Acts upstream of or within heart development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See wasf2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (43523675..43543128)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (43928061..43947531)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene AT hook, DNA binding motif, containing 1 Neighboring gene probable methyltransferase-like protein 24 Neighboring gene G protein-coupled receptor 3 Neighboring gene CD164 sialomucin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. Edwards JJ, et al. JACC Basic Transl Sci, 2020 Apr. PMID 32368696, Free PMC Article
  2. The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Luo Z, et al. Dev Cell, 2022 Jul 11. PMID 35709765, Free PMC Article
  3. Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish. English MA, et al. Dev Dyn, 2012 May. PMID 22411201, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56010

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Arp2/3 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
actin-binding protein WASF2
Names
WAS protein family, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328190.1 → NP_001315119.1  actin-binding protein WASF2

    Status: VALIDATED

    Source sequence(s)
    BX649384
    UniProtKB/TrEMBL
    A0A8M1P4I3, Q1LVV3
    Related
    ENSDARP00000104195.2, ENSDART00000113031.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    43523675..43543128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352208.3 → XP_017207697.1  actin-binding protein WASF2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1P4I3, Q1LVV3

  2. XM_068215052.1 → XP_068071153.1  actin-binding protein WASF2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1P4I3, Q1LVV3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201081.1: Suppressed sequence

    Description
    NM_201081.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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