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sh2d3cb SH2 domain containing 3Cb [ Danio rerio (zebrafish) ]

Gene ID: 394051, updated on 4-Jan-2025

Summary

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Official Symbol
sh2d3cbprovided by ZNC
Official Full Name
SH2 domain containing 3Cbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1052
See related
Ensembl:ENSDARG00000104555 AllianceGenome:ZFIN:ZDB-GENE-040426-1052
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sh2d3c; zgc:56490
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to act upstream of or within small GTPase-mediated signal transduction. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See sh2d3cb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (65124168..65158203, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (64434991..64469206, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene microRNA 219-2 Neighboring gene torsin family 2, member A Neighboring gene cilia and flagella associated protein 157 Neighboring gene collagen, type XXVII, alpha 1b Neighboring gene microRNA 455 Neighboring gene uncharacterized LOC110439792

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Takada N, et al. Dev Dyn, 2010 Jul. PMID 20549738
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC56490

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH2 domain containing 3Cb
Names
SH2 domain containing 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201076.1 → NP_957370.1  SH2 domain containing 3Cb

    See identical proteins and their annotated locations for NP_957370.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049321
    UniProtKB/TrEMBL
    Q7ZUD0
    Related
    ENSDARP00000140658.1, ENSDART00000171656.2
    Conserved Domains (2) summary
    cd10337
    Location:43 → 178
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:365 → 533
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    65124168..65158203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476041.2 → XP_021331716.1  SH2 domain containing 3Cb isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCW0
    Conserved Domains (2) summary
    cd10337
    Location:37 → 172
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:359 → 527
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_005165604.5 → XP_005165661.1  SH2 domain containing 3Cb isoform X1

    See identical proteins and their annotated locations for XP_005165661.1

    UniProtKB/TrEMBL
    A0A8M2BCW0
    Conserved Domains (2) summary
    cd10337
    Location:37 → 172
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:359 → 527
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394621.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    41807..71488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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