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ttll1 tubulin tyrosine ligase-like family, member 1 [ Danio rerio (zebrafish) ]

Gene ID: 393994, updated on 9-Dec-2024

Summary

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Official Symbol
ttll1provided by ZNC
Official Full Name
tubulin tyrosine ligase-like family, member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1326
See related
Ensembl:ENSDARG00000090778 AllianceGenome:ZFIN:ZDB-GENE-040426-1326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63993
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within protein modification process. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be active in ciliary basal body. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See ttll1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (77919953..77932571)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (76535264..76547869)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain-containing protein 3-like Neighboring gene uncharacterized LOC137491387 Neighboring gene si:zfos-2131b9.2 Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene ADP-ribosylation factor GTPase activating protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. Zadra I, et al. Nat Commun, 2022 Nov 21. PMID 36414642, Free PMC Article
  2. Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility. Pathak N, et al. J Biol Chem, 2011 Apr 1. PMID 21262966, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC63993

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polyglutamylase complex subunit TTLL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320519.1 → NP_001307448.1  polyglutamylase complex subunit TTLL1

    Status: VALIDATED

    Source sequence(s)
    CU695158
    UniProtKB/TrEMBL
    A0A8M1P2G8, F8W385
    Related
    ENSDARP00000124463.1, ENSDART00000150171.3
    Conserved Domains (1) summary
    pfam03133
    Location:59 → 365
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    77919953..77932571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354981.3 → XP_017210470.1  polyglutamylase complex subunit TTLL1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1P2G8, F8W385
    Conserved Domains (1) summary
    pfam03133
    Location:59 → 365
    TTL; Tubulin-tyrosine ligase family

  2. XM_017354980.3 → XP_017210469.1  polyglutamylase complex subunit TTLL1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1P2G8, F8W385
    Conserved Domains (1) summary
    pfam03133
    Location:59 → 365
    TTL; Tubulin-tyrosine ligase family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201019.1: Suppressed sequence

    Description
    NM_201019.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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