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nek4 NIMA-related kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 393987, updated on 9-Dec-2024

Summary

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Official Symbol
nek4provided by ZNC
Official Full Name
NIMA-related kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1392
See related
Ensembl:ENSDARG00000040152 AllianceGenome:ZFIN:ZDB-GENE-040426-1392
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64176
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in DNA damage response. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human NEK4 (NIMA related kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See nek4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3994747..4023997, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3975360..4004613, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene calcium/calmodulin-dependent protein kinase Ib Neighboring gene coiled-coil domain containing 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Peña OA, et al. Front Cell Dev Biol, 2021. PMID 34589480, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC64176

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek4
Names
NIMA (never in mitosis gene a)-related kinase 4
NP_957306.1
XP_005155743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201012.1 → NP_957306.1  serine/threonine-protein kinase Nek4

    See identical proteins and their annotated locations for NP_957306.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054633
    UniProtKB/TrEMBL
    Q7T299
    Related
    ENSDARP00000058727.4, ENSDART00000058728.6
    Conserved Domains (2) summary
    smart00220
    Location:4 → 259
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:3 → 259
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    3994747..4023997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155686.5 → XP_005155743.1  serine/threonine-protein kinase Nek4 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B266
    Conserved Domains (2) summary
    smart00220
    Location:4 → 259
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:3 → 259
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4
Nucleotide Protein
Heading Accession and Version

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