bhlhe22 basic helix-loop-helix family, member e22 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bhlhe22provided by ZNC
Official Full Name: basic helix-loop-helix family, member e22provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1411
See related: Ensembl:ENSDARG00000058039 AllianceGenome:ZFIN:ZDB-GENE-040426-1411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bhlhb5; Beta3.1; zgc:64225; wu:fq25e11
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be active in nucleus. Is expressed in immature eye; midbrain neural rod; nervous system; neural plate; and neural tube. Orthologous to human BHLHE22 (basic helix-loop-helix family member e22). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (24461558..24463346)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (24316384..24318172)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations suggest a different regulatory mechanism on bhlhe22 expression by smarca4 and irx7
Title: Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas.
atoh1.2 and beta3.1 are transcribed in distinct precursors.
Title: atoh1.2 and beta3.1 are two new bHLH-encoding genes expressed in selective precursor cells of the zebrafish anterior hindbrain.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: class E basic helix-loop-helix protein 22

Names: Beta3a; basic helix-loop-helix domain containing, class B, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200955.1 → NP_957249.2 class E basic helix-loop-helix protein 22

Status: VALIDATED

Source sequence(s)

BC053312

UniProtKB/TrEMBL

A0A8M1PC14, F1R9F5, Q7T301

Related

ENSDARP00000153194.1, ENSDART00000182424.1

Conserved Domains (1) summary

smart00353
Location:136 → 190

HLH; helix loop helix domain