kcmf1 potassium channel modulatory factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kcmf1provided by ZNC
Official Full Name: potassium channel modulatory factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1383
See related: Ensembl:ENSDARG00000067656 AllianceGenome:ZFIN:ZDB-GENE-040426-1383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64160
Summary: Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in negative regulation of HRI-mediated signaling; protein K63-linked ubiquitination; and synaptic signaling. Predicted to be located in late endosome and lysosome. Predicted to be active in plasma membrane. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (55708637..55752147, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (55049473..55082202, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of HRI-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase KCMF1

Names: RING-type E3 ubiquitin transferase KCMF1

NP_957246.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200952.2 → NP_957246.1 E3 ubiquitin-protein ligase KCMF1

See identical proteins and their annotated locations for NP_957246.1

Status: PROVISIONAL

Source sequence(s)

AY394941

UniProtKB/Swiss-Prot

Q7T321

Related

ENSDARP00000088195.4, ENSDART00000097424.6

Conserved Domains (3) summary

cd02338
Location:7 → 55

ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...

pfam05605
Location:76 → 137

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam14571
Location:260 → 330

Di19_C; Stress-induced protein Di19, C-terminal