fbxo32 F-box protein 32 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbxo32provided by ZNC
Official Full Name: F-box protein 32provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1040
See related: Ensembl:ENSDARG00000040277 AllianceGenome:ZFIN:ZDB-GENE-040426-1040
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: atrogin1; zgc:56479
Summary: Acts upstream of or within several processes, including cardiac muscle tissue morphogenesis; larval locomotory behavior; and muscle cell cellular homeostasis. Located in cytoplasm. Is expressed in cardiac muscle cell; muscle; skeletal muscle; skeletal muscle cell; and yolk syncytial layer. Orthologous to human FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (25259313..25272633)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (25344281..25357601)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.
Title: Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: F-box only protein 32

Names: atrogin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200917.1 → NP_957211.1 F-box only protein 32

See identical proteins and their annotated locations for NP_957211.1

Status: PROVISIONAL

Source sequence(s)

BC052112

UniProtKB/TrEMBL

Q7ZTY2

Related

ENSDARP00000058937.4, ENSDART00000058938.5

Conserved Domains (2) summary

pfam06881
Location:254 → 303

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

pfam12937
Location:226 → 272

F-box-like; F-box-like