gcdha glutaryl-CoA dehydrogenase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gcdhaprovided by ZNC
Official Full Name: glutaryl-CoA dehydrogenase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1855
See related: Ensembl:ENSDARG00000037057 AllianceGenome:ZFIN:ZDB-GENE-040426-1855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gcdh; zgc:56505; zgc:77704
Summary: Predicted to enable fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase and fatty-acyl-CoA biosynthetic process. Is expressed in alar plate midbrain region; eye; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (8314553..8328453)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (8079014..8092914)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables glutaryl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutaryl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty-acyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutaryl-CoA dehydrogenase a

Names: glutaryl-Coenzyme A dehydrogenase

NP_957180.1

EC 1.3.8.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200886.1 → NP_957180.1 glutaryl-CoA dehydrogenase a

See identical proteins and their annotated locations for NP_957180.1

Status: PROVISIONAL

Source sequence(s)

BC063972

UniProtKB/TrEMBL

A0A8M1PI52, Q6P3I8

Related

ENSDARP00000112983.1, ENSDART00000147793.3

Conserved Domains (2) summary

cd01151
Location:51 → 437

GCD; Glutaryl-CoA dehydrogenase

COG1960
Location:63 → 437

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]