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snrkb SNF related kinase b [ Danio rerio (zebrafish) ]

Gene ID: 393806, updated on 4-Jan-2025

Summary

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Official Symbol
snrkbprovided by ZNC
Official Full Name
SNF related kinase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1724
See related
Ensembl:ENSDARG00000017665 AllianceGenome:ZFIN:ZDB-GENE-040426-1724
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
snrk1; zgc:73231
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within hemangioblast cell differentiation and protein phosphorylation. Is expressed in brain; neural tube; pronephric tubule; and trunk vasculature. Orthologous to human SNRK (SNF related kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See snrkb in Genome Data Viewer
Location:
chromosome: 25
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (13498188..13526319)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (13393972..13430269)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 1 Neighboring gene lactate dehydrogenase D Neighboring gene anoctamin 10b Neighboring gene fatty acid 2-hydroxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. Chun CZ, et al. Blood, 2009 Jan 29. PMID 18723694, Free PMC Article
  2. Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy. Ding Y, et al. Dis Model Mech, 2023 May 1. PMID 35481478, Free PMC Article
  3. G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Zhang P, et al. Cell Res, 2015 Oct. PMID 26358189, Free PMC Article
  4. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC73231

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hemangioblast cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hemangioblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SNF related kinase b
Names
SNF related kinase 1
snrk-1
NP_957127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200833.1 → NP_957127.1  SNF related kinase b

    See identical proteins and their annotated locations for NP_957127.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060922
    UniProtKB/TrEMBL
    A0A8M2BLK2, F1QEF3, Q6P954
    Related
    ENSDARP00000025934.7, ENSDART00000015710.8
    Conserved Domains (3) summary
    smart00220
    Location:16 → 269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14339
    Location:290 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    13498188..13526319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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