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fhit - fragile histidine triad diadenosine triphosphatase

Predicted to enable bis(5'-adenosyl)-triphosphatase activity and ubiquitin protein ligase binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and nucleotide metabolic process. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa