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viaf viral IAP-associated factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39364, updated on 9-Dec-2024

Summary

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Official Symbol
viafprovided by FlyBase
Official Full Name
viral IAP-associated factorprovided by FlyBase
Primary source
FLYBASE:FBgn0036237
Locus tag
Dmel_CG18593
See related
AllianceGenome:FB:FBgn0036237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0134798.17; anon-WO0134798.18; CG18593; Dmel\CG18593; Viaf; VIAF; viaf1
Summary
Predicted to be involved in negative regulation of chaperone-mediated protein folding and protein folding. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in cytoplasm. Is expressed in dorsal pharyngeal muscle primordium; larval muscle system; organism; and somatic muscle primordium. Orthologous to several human genes including PDCL3 (phosducin like 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See viaf in Genome Data Viewer
Location:
68F1-68F1; 3-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11991853..11993179, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11984953..11986279, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Grip163 Neighboring gene Pop2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HucR, a novel uric acid-responsive member of the MarR family of transcriptional regulators from Deinococcus radiodurans. Wilkinson SP, et al. J Biol Chem, 2004 Dec 3. PMID 15448166
  2. VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. Wilkinson JC, et al. J Biol Chem, 2004 Dec 3. PMID 15371430
  3. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
  4. Combining mapping and arraying: An approach to candidate gene identification. Wayne ML, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12415114, Free PMC Article
  5. Sequential activation of signaling pathways during innate immune responses in Drosophila. Boutros M, et al. Dev Cell, 2002 Nov. PMID 12431377

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in negative regulation of chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
viral IAP-associated factor
Names
CG18593-PA
viaf-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11991853..11993179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079308.2 → NP_524032.2  viral IAP-associated factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524032.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86G89, Q8MR62, Q9VTS2
    Related
    FBpp0075794, FBtr0076062
    Conserved Domains (1) summary
    cd02988
    Location:8 → 210
    Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR62.1 Q8MR62

Gene LinkOut

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