kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kdelr3provided by ZNC
Official Full Name: KDEL endoplasmic reticulum protein retention receptor 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1387
See related: Ensembl:ENSDARG00000040912 AllianceGenome:ZFIN:ZDB-GENE-040426-1387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64171
Summary: Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum. Predicted to colocalize with COPI-coated vesicle membrane. Is expressed in several structures, including hatching gland; median fin fold; notochord; pectoral fin musculature; and polster. Orthologous to human KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (163240..180635, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (225858..243253, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ER retention sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables ER retention sequence binding	IEA Inferred from Electronic Annotation more info
enables KDEL sequence binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein retention in ER lumen	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein retention in ER lumen	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with COPI-coated vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ER lumen protein-retaining receptor 3

Names: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200640.2 → NP_956934.2 ER lumen protein-retaining receptor 3

Status: VALIDATED

Source sequence(s)

CR391944

UniProtKB/Swiss-Prot

Q6PFS5

Related

ENSDARP00000059955.4, ENSDART00000059956.5

Conserved Domains (1) summary

pfam00810
Location:28 → 169

ER_lumen_recept; ER lumen protein retaining receptor