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cct4 chaperonin containing TCP1, subunit 4 (delta) [ Danio rerio (zebrafish) ]

Gene ID: 393555, updated on 9-Dec-2024

Summary

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Official Symbol
cct4provided by ZNC
Official Full Name
chaperonin containing TCP1, subunit 4 (delta)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1421
See related
Ensembl:ENSDARG00000013475 AllianceGenome:ZFIN:ZDB-GENE-040426-1421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:65789; zgc:77192
Summary
Predicted to enable unfolded protein binding activity. Acts upstream of or within eye morphogenesis and response to hypoxia. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including head; immature eye; midbrain; muscle; and pectoral fin bud. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See cct4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (53701801..53714843, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (53068959..53082001, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene exportin 1 (CRM1 homolog, yeast) a Neighboring gene FAM161 centrosomal protein A Neighboring gene pseudouridine synthase 10 Neighboring gene v-akt murine thymoma viral oncogene homolog 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Role of TRiC-enhanced Actin Folding in Leber Congenital Amaurosis. Berger S, et al. J Ophthalmic Vis Res, 2023 Jan-Mar. PMID 36937198, Free PMC Article
  2. In Vivo Function of the Chaperonin TRiC in α-Actin Folding during Sarcomere Assembly. Berger J, et al. Cell Rep, 2018 Jan 9. PMID 29320728
  3. Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish. van der Meer DL, et al. Am J Physiol Regul Integr Comp Physiol, 2005 Nov. PMID 15994372
  4. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Lyche JL, et al. Aquat Toxicol, 2011 Apr. PMID 21356182
  5. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Lyche JL, et al. J Toxicol Environ Health A, 2010. PMID 20526952

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC65789

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
T-complex protein 1 subunit delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200583.1 → NP_956877.1  T-complex protein 1 subunit delta

    See identical proteins and their annotated locations for NP_956877.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056719
    UniProtKB/TrEMBL
    A0A8M1PEN3, Q6PH46
    Related
    ENSDARP00000025466.5, ENSDART00000026409.7
    Conserved Domains (2) summary
    cd03338
    Location:20 → 532
    TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    pfam00118
    Location:38 → 533
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    53701801..53714843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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