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gadd45aa growth arrest and DNA-damage-inducible, alpha, a [ Danio rerio (zebrafish) ]

Gene ID: 393548, updated on 9-Dec-2024

Summary

Official Symbol
gadd45aaprovided by ZNC
Official Full Name
growth arrest and DNA-damage-inducible, alpha, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1501
See related
Ensembl:ENSDARG00000043581 AllianceGenome:ZFIN:ZDB-GENE-040426-1501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gadd45al; zgc:65993; zgc:77480
Summary
Acts upstream of or within paraxial mesoderm development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; endoderm; eye; otic placode; and solid lens vesicle. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See gadd45aa in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (10280667..10284572)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (10497068..10500973)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene NOP2/Sun RNA methyltransferase 4 Neighboring gene diencephalon/mesencephalon homeobox 1a Neighboring gene guanine nucleotide binding protein (G protein), gamma 12a Neighboring gene Wnt ligand secretion mediator

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC65993

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
growth arrest and DNA-damage-inducible, alpha, a
Names
gadd45alpha
growth arrest and DNA damage 45 alpha
growth arrest and DNA-damage-inducible, alpha like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200576.2NP_956870.2  growth arrest and DNA-damage-inducible, alpha, a

    Status: VALIDATED

    Source sequence(s)
    CU693482, EH446990
    UniProtKB/TrEMBL
    A0A8M1PBG0, F1R8Z0
    Related
    ENSDARP00000063995.3, ENSDART00000063996.4
    Conserved Domains (1) summary
    pfam01248
    Location:20102
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    10280667..10284572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)