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fzd6 frizzled class receptor 6 [ Danio rerio (zebrafish) ]

Gene ID: 393533, updated on 4-Jan-2025

Summary

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Official Symbol
fzd6provided by ZNC
Official Full Name
frizzled class receptor 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1451
See related
Ensembl:ENSDARG00000104874 AllianceGenome:ZFIN:ZDB-GENE-040426-1451
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:65879; zgc:77440
Summary
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within angiogenesis and embryonic cranial skeleton morphogenesis. Predicted to be located in apical plasma membrane; cell surface; and cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Is expressed in head; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 1. Orthologous to human FZD6 (frizzled class receptor 6). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See fzd6 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54513267..54521652)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (54546169..54551535)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003335549.1 (765..2458, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene CDC-like kinase 2b Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene uncharacterized LOC137487998 Neighboring gene uncharacterized LOC103908998

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family. Cvjetkovic N, et al. Mol Genet Genomic Med, 2015 Sep. PMID 26436110, Free PMC Article
  2. Expression of five frizzleds during zebrafish craniofacial development. Sisson BE, et al. Gene Expr Patterns, 2009 Oct. PMID 19595791, Free PMC Article
  3. Single-cell transcriptomic analysis of zebrafish cranial neural crest reveals spatiotemporal regulation of lineage decisions during development. Tatarakis D, et al. Cell Rep, 2021 Dec 21. PMID 34936864, Free PMC Article
  4. Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish. Shitasako S, et al. Dev Neurobiol, 2017 Oct. PMID 28589698
  5. Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis. Uribe RA, et al. Dev Biol, 2012 Nov 15. PMID 22981606, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC65879

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
frizzled-6
Names
frizzled homolog 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200561.2 → NP_956855.1  frizzled-6 precursor

    See identical proteins and their annotated locations for NP_956855.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065361
    UniProtKB/TrEMBL
    Q6P0Y7
    Related
    ENSDARP00000140294.2, ENSDART00000161923.2
    Conserved Domains (3) summary
    cd07450
    Location:20 → 154
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    cd14964
    Location:198 → 222
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:188 → 508
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    54513267..54521652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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