Rpt4R Regulatory particle triple-A ATPase 4-related [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rpt4Rprovided by FlyBase
Official Full Name: Regulatory particle triple-A ATPase 4-relatedprovided by FlyBase
Primary source: FLYBASE:FBgn0036224
Locus tag: Dmel_CG7257
See related: AllianceGenome:FB:FBgn0036224
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 7257; CG7257; DmCG7257; Dmel\CG7257; Dm_Rpt4c
Summary: Predicted to enable proteasome-activating activity. Predicted to be involved in ERAD pathway; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in organism. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11941912..11943485)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11935012..11936585)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome-activating activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	ISS Inferred from Sequence or Structural Similarity more info

NP_001287039.1

NP_648525.1

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The following sections contain reference sequences that belong to a specific genome build. Explain