ptpn2a protein tyrosine phosphatase non-receptor type 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpn2aprovided by ZNC
Official Full Name: protein tyrosine phosphatase non-receptor type 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1196
See related: Ensembl:ENSDARG00000016481 AllianceGenome:ZFIN:ZDB-GENE-040426-1196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptpn2; PTP-1B; zgc:63623; hm:zeh1546
Summary: Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and protein kinase binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (10055428..10071874, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (10164526..10180972, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 2a

Names: protein tyrosine phosphatase 1B; protein tyrosine phosphatase, non-receptor type 2, a

NP_956760.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200466.2 → NP_956760.2 tyrosine-protein phosphatase non-receptor type 2a

Status: VALIDATED

Source sequence(s)

CR388383, CR533572

UniProtKB/TrEMBL

A0A8M1PCX4, F1Q8I4

Related

ENSDARP00000118955.1, ENSDART00000136168.3

Conserved Domains (2) summary

smart00194
Location:11 → 274

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:41 → 274

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...