pcolce2b procollagen C-endopeptidase enhancer 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcolce2bprovided by ZNC
Official Full Name: procollagen C-endopeptidase enhancer 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1177
See related: Ensembl:ENSDARG00000055575 AllianceGenome:ZFIN:ZDB-GENE-040426-1177
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63590
Summary: Predicted to enable collagen binding activity and peptidase activator activity. Predicted to be located in extracellular region. Orthologous to human PCOLCE2 (procollagen C-endopeptidase enhancer 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (5871589..5889763, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (5842260..5860434, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: procollagen C-endopeptidase enhancer 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200460.1 → NP_956754.1 procollagen C-endopeptidase enhancer 2b precursor

See identical proteins and their annotated locations for NP_956754.1

Status: PROVISIONAL

Source sequence(s)

BC055153

UniProtKB/TrEMBL

Q7SY25

Related

ENSDARP00000072417.2, ENSDART00000077951.3

Conserved Domains (3) summary

cd00041
Location:28 → 138

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd03576
Location:290 → 413

NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...

pfam00431
Location:149 → 260

CUB; CUB domain