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Pi3K68D - Phosphatidylinositol 3-kinase 68D

Enables several functions, including SH3 domain binding activity; phosphatidylinositol kinase activity; and small GTPase binding activity. Involved in cortical actin cytoskeleton organization; negative regulation of epidermal growth factor receptor signaling pathway; and phosphatidylinositol phosphate biosynthetic process. Located in endosome membrane. Is expressed in several structures, including adult brain; adult head; adult pars intercerebralis; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) and PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Pi3K68D

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Species Gene Architecture aa