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ncor1 nuclear receptor corepressor 1 [ Danio rerio (zebrafish) ]

Gene ID: 393246, updated on 9-Dec-2024

Summary

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Official Symbol
ncor1provided by ZNC
Official Full Name
nuclear receptor corepressor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-993
See related
Ensembl:ENSDARG00000035285 AllianceGenome:ZFIN:ZDB-GENE-040426-993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ncor; zgc:56355
Summary
Predicted to enable nuclear thyroid hormone receptor binding activity and transcription corepressor activity. Acts upstream of or within anterior/posterior pattern specification; hindbrain development; and neutrophil differentiation. Predicted to be located in chromatin. Is expressed in several structures, including epidermis; head; liver; pleuroperitoneal region; and ventricular system. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See ncor1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41878243..41996511, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (41278099..41396358, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-65b12.12 Neighboring gene uncharacterized LOC137495617 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene si:ch211-202a12.4 Neighboring gene centromere protein V

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Corepressor diversification by alternative mRNA splicing is species specific. Privalsky ML, et al. BMC Evol Biol, 2016 Oct 19. PMID 27756201, Free PMC Article
  2. Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Linney E, et al. Gene, 2011 Oct 15. PMID 21767619, Free PMC Article
  3. High-resolution in situ hybridization to whole-mount zebrafish embryos. Thisse C, et al. Nat Protoc, 2008. PMID 18193022
  4. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis. Li J, et al. Dev Dyn, 2014 Dec. PMID 25156564
  5. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Shi B, et al. Genome Biol, 2020 May 18. PMID 32423473, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
    Title: Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC56355

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hindbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor corepressor 1
Names
nuclear receptor co-repressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200276.2 → NP_956570.2  nuclear receptor corepressor 1

    See identical proteins and their annotated locations for NP_956570.2

    Status: PROVISIONAL

    Source sequence(s)
    EF016488
    UniProtKB/TrEMBL
    A0A8M2BCM0, A8B6H7
    Conserved Domains (3) summary
    smart00717
    Location:641 → 686
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:641 → 684
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam15784
    Location:141 → 225
    GPS2_interact; G-protein pathway suppressor 2-interacting domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    41878243..41996511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301627.4 → XP_009299902.1  nuclear receptor corepressor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASH4, A0A8M3B2M9
    Related
    ENSDARP00000120166.1, ENSDART00000143573.2
    Conserved Domains (3) summary
    smart00717
    Location:641 → 686
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:641 → 684
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam15784
    Location:141 → 225
    GPS2_interact; G-protein pathway suppressor 2-interacting domain

  2. XM_009301634.4 → XP_009299909.1  nuclear receptor corepressor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AZS8, A0A8M3B2N4
    Conserved Domains (2) summary
    smart00717
    Location:152 → 197
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:152 → 195
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. XM_021476034.2 → XP_021331709.1  nuclear receptor corepressor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AZS8, A0A8M9Q2Z1
    Conserved Domains (1) summary
    smart00717
    Location:157 → 202
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  4. XM_009301633.4 → XP_009299908.1  nuclear receptor corepressor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASM4, A0A8M3AZS8
    Related
    ENSDARP00000088345.3, ENSDART00000097574.4
    Conserved Domains (2) summary
    smart00717
    Location:156 → 201
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:156 → 199
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394603.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    113020..231765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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