wdr45b WD repeat domain 45B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr45bprovided by ZNC
Official Full Name: WD repeat domain 45Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-863
See related: Ensembl:ENSDARG00000021557 AllianceGenome:ZFIN:ZDB-GENE-040426-863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: WIPI-3; wdr45l; zgc:56002
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (42592..46985, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (269291..273684, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc33c03.x1 (e-PCR)
- UniSTS:193571

G46009 (e-PCR)
- UniSTS:106811

G45250 (e-PCR)
- UniSTS:106052

G47618 (e-PCR)
- UniSTS:108392

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein lipidation involved in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat domain phosphoinositide-interacting protein 3

Names: WD repeat-containing protein 45-like; WD repeat-containing protein 45B; WDR45-like protein; wdr45 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200240.2 → NP_956534.2 WD repeat domain phosphoinositide-interacting protein 3

Status: VALIDATED

Source sequence(s)

CU611036

UniProtKB/Swiss-Prot

Q7ZUW6

UniProtKB/TrEMBL

A0A8N7V004, A8KC31

Related

ENSDARP00000126974.1, ENSDART00000152327.3

Conserved Domains (3) summary

COG2319
Location:80 → 295

WD40; WD40 repeat [General function prediction only]

sd00039
Location:145 → 183

7WD40; WD40 repeat [structural motif]

cl02567
Location:34 → 257

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...