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trim25 tripartite motif containing 25 [ Danio rerio (zebrafish) ]

Gene ID: 393144, updated on 4-Jan-2025

Summary

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Official Symbol
trim25provided by ZNC
Official Full Name
tripartite motif containing 25provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-797
See related
Ensembl:ENSDARG00000104396 AllianceGenome:ZFIN:ZDB-GENE-040426-797
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55773
Summary
Predicted to enable ligase activity and zinc ion binding activity. Acts upstream of or within regulation of RIG-I signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including gill; integument; male organism; muscle; and pleuroperitoneal region. Orthologous to human TRIM25 (tripartite motif containing 25). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See trim25 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (18388327..18400606, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (21916798..21929308, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene si:dkey-31g6.6 Neighboring gene diacylglycerol kinase, epsilon Neighboring gene RAB11 family interacting protein 4 (class II) b Neighboring gene uncharacterized LOC137490201

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular characterization of tripartite motif protein 25 (TRIM25) involved in ERα-mediated transcription in the Korean rose bitterling Rhodeus uyekii. Kong HJ, et al. Comp Biochem Physiol B Biochem Mol Biol, 2012 Sep. PMID 22642868
  2. Zebrafish ISG15 exerts a strong antiviral activity against RNA and DNA viruses and regulates the interferon response. Langevin C, et al. J Virol, 2013 Sep. PMID 23824820, Free PMC Article
  3. FTR67, a member of the fish-specific finTRIM family, triggers IFN pathway and against spring viremia of carp virus. Huo S, et al. Fish Shellfish Immunol, 2020 Aug. PMID 32334126
  4. Behavioural fever is a synergic signal amplifying the innate immune response. Boltaña S, et al. Proc Biol Sci, 2013 Sep 7. PMID 23843398, Free PMC Article
  5. Origin and evolution of the zinc finger antiviral protein. Gonçalves-Carneiro D, et al. PLoS Pathog, 2021 Apr. PMID 33901262, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity.
    Title: Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity.
  2. Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination.
    Title: Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC55773

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin/ISG15 ligase TRIM25
NP_956469.1
XP_017211938.1
XP_068077767.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200175.1 → NP_956469.1  E3 ubiquitin/ISG15 ligase TRIM25

    See identical proteins and their annotated locations for NP_956469.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045450
    UniProtKB/TrEMBL
    Q7ZVQ7
    Related
    ENSDARP00000134454.1, ENSDART00000164891.2
    Conserved Domains (4) summary
    pfam00643
    Location:152 → 184
    zf-B_box; B-box zinc finger
    cl02614
    Location:482 → 650
    SPRY; SPRY domain
    cl17238
    Location:16 → 56
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:199 → 307
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    18388327..18400606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356449.3 → XP_017211938.1  E3 ubiquitin/ISG15 ligase TRIM25 isoform X2

    UniProtKB/TrEMBL
    A0A2R8QTG3, A0A8M6Z112
    Related
    ENSDARP00000156782.1, ENSDART00000179797.1
    Conserved Domains (4) summary
    cd00162
    Location:15 → 57
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:152 → 184
    zf-B_box; B-box zinc finger
    cl02614
    Location:473 → 641
    SPRY; SPRY domain
    cl23765
    Location:199 → 307
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. XM_068221666.1 → XP_068077767.1  E3 ubiquitin/ISG15 ligase TRIM25 isoform X1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394636.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    248769..261071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395252.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    100896..113239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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