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irak4 interleukin-1 receptor-associated kinase 4 [ Danio rerio (zebrafish) ]

Gene ID: 393132, updated on 9-Dec-2024

Summary

Official Symbol
irak4provided by ZNC
Official Full Name
interleukin-1 receptor-associated kinase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-738
See related
Ensembl:ENSDARG00000100534 AllianceGenome:ZFIN:ZDB-GENE-040426-738
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55553
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Acts upstream of or within positive regulation of DNA-templated transcription and response to bacterium. Predicted to be located in cytoplasm. Is expressed in brain; gill; heart; immune system; and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See irak4 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (765302..774471, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336182.2 (668..9837, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489307 Neighboring gene uncharacterized LOC137489308 Neighboring gene transmembrane protein 117 Neighboring gene twinfilin actin-binding protein 1a Neighboring gene GRAM domain-containing protein 2A Neighboring gene uncharacterized LOC101886811

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Clone Names

  • MGC55553

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables kinase activity  
enables magnesium ion binding  
enables nucleotide binding  
enables protein kinase activity  
enables protein serine/threonine kinase activity  
enables transferase activity  
Component Evidence Code Pubs
located_in cytoplasm  

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 4
NP_956457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200163.1 → NP_956457.1  interleukin-1 receptor-associated kinase 4

    See identical proteins and their annotated locations for NP_956457.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045381
    UniProtKB/TrEMBL
    Q7ZVW7
    Related
    ENSDARP00000136170.2, ENSDART00000160386.2
    Conserved Domains (2) summary
    cd08793
    Location:8 → 107
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cl21453
    Location:188 → 353
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    765302..774471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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