Ufd1 Ubiquitin fusion-degradation 1-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ufd1provided by FlyBase
Official Full Name: Ubiquitin fusion-degradation 1-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0036136
Locus tag: Dmel_CG6233
See related: AllianceGenome:FB:FBgn0036136
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.405; CG6233; Dmel\CG6233; dUfd1; dUFD1L; Udf1; Ufd-1; ufd1; UFD1; Ufd1 like; ufd1-like; Ufd1-like; UfD1-like; Ufd1L
Summary: Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to virus; negative regulation of smoothened signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in adult head; embryonic/larval garland cell; gonad; and organism. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11121966..11123216, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11115066..11116316, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

differing neuronal functions of Npl4 and Ufd1 in vivo
Title: Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	NAS Non-traceable Author Statement more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain