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galla-2 galla-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39221, updated on 4-Jan-2025

Summary

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Official Symbol
galla-2provided by FlyBase
Official Full Name
galla-2provided by FlyBase
Primary source
FLYBASE:FBgn0036107
Locus tag
Dmel_CG7949
See related
AllianceGenome:FB:FBgn0036107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7949; CIAO2B; Dmel\CG7949; Galla-2; galla2; Galla2
Summary
Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is expressed in larval imaginal tissue. Orthologous to human CIAO2B (cytosolic iron-sulfur assembly component 2B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See galla-2 in Genome Data Viewer
Location:
67F1-67F1; 3-33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10882890..10883573)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10875990..10876673)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 4 Neighboring gene uncharacterized protein Neighboring gene OXA1L mitochondrial inner membrane protein Neighboring gene Cuticular protein 67Fa1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crumbs interacts with Xpd for nuclear division control in Drosophila. Yeom E, et al. Oncogene, 2015 May 21. PMID 25065591
  2. Structural insights into Fe-S protein biogenesis by the CIA targeting complex. Kassube SA, et al. Nat Struct Mol Biol, 2020 Aug. PMID 32632277
  3. Ciao1 interacts with Crumbs and Xpd to regulate organ growth in Drosophila. Jung J, et al. Cell Death Dis, 2020 May 13. PMID 32404863, Free PMC Article
  4. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Nag RN, et al. Development, 2018 Jan 25. PMID 29361561, Free PMC Article
  5. Crumbs, Galla and Xpd are required for Kinesin-5 regulation in mitosis and organ growth in Drosophila. Hwang JH, et al. J Cell Sci, 2020 Jun 23. PMID 32501288

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation by [4Fe-4S] cluster transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cytosolic [4Fe-4S] assembly targeting complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
galla-2
Names
CG7949-PA
galla-2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10882890..10883573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140159.2 → NP_648416.1  galla-2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648416.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTC4
    UniProtKB/TrEMBL
    A0A1B2AL76, Q29QJ3
    Related
    FBpp0075999
    Conserved Domains (1) summary
    cl00941
    Location:1 → 154
    DUF59; Domain of unknown function DUF59
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTC4.1 Q9VTC4

Gene LinkOut

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Chemical Information
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