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NijA Ninjurin A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39215, updated on 9-Dec-2024

Summary

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Official Symbol
NijAprovided by FlyBase
Official Full Name
Ninjurin Aprovided by FlyBase
Primary source
FLYBASE:FBgn0036101
Locus tag
Dmel_CG6449
See related
AllianceGenome:FB:FBgn0036101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6449; Dmel\CG6449; nija; nijA; ninA; NINJ-A
Summary
Involved in several processes, including cell adhesion; cytolysis; and negative regulation of cell adhesion. Is active in extracellular region and plasma membrane. Is expressed in larval optic neuroblast. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See NijA in Genome Data Viewer
Location:
67E7-67E7; 3-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10694360..10696877, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10687460..10689977, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) 13 kDa B subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44544

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Ninjurin A induces nonapoptotic cell death. Broderick S, et al. PLoS One, 2012. PMID 23028562, Free PMC Article
  2. NINJ1 mediates plasma membrane rupture during lytic cell death. Kayagaki N, et al. Nature, 2021 Mar. PMID 33472215
  3. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. Patterson RA, et al. PLoS One, 2013. PMID 23637905, Free PMC Article
  4. Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system. Kang L, et al. BMC Genomics, 2016 Mar 15. PMID 26979755, Free PMC Article
  5. HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. Qiu C, et al. J Mol Cell Biol, 2019 Feb 1. PMID 29750417, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ninjurin A
Names
CG6449-PA
CG6449-PB
CG6449-PC
CG6449-PD
NijA-PA
NijA-PB
NijA-PC
NijA-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10694360..10696877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274758.2 → NP_001261687.1  ninjurin A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261687.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHZ8
    Conserved Domains (1) summary
    pfam04923
    Location:110 → 210
    Ninjurin; Ninjurin

  2. NM_140153.5 → NP_648410.1  ninjurin A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648410.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTB5
    Related
    FBpp0088536
    Conserved Domains (1) summary
    pfam04923
    Location:126 → 226
    Ninjurin; Ninjurin

  3. NM_206317.2 → NP_996039.1  ninjurin A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996039.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPN9
    Conserved Domains (1) summary
    pfam04923
    Location:114 → 214
    Ninjurin; Ninjurin

  4. NM_206318.2 → NP_996040.1  ninjurin A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996040.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PHZ8, Q8MPN9, Q8MPP0, Q8SYI2, Q9VTB5
    Conserved Domains (1) summary
    pfam04923
    Location:130 → 230
    Ninjurin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MPP0.1 Q8MPP0

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