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Gem3 Gemin 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39195, updated on 9-Dec-2024

Summary

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Official Symbol
Gem3provided by FlyBase
Official Full Name
Gemin 3provided by FlyBase
Primary source
FLYBASE:FBgn0011802
Locus tag
Dmel_CG6539
See related
AllianceGenome:FB:FBgn0011802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA.LD05563; BcDNA:LD05563; CG6539; dGem3; Dhh1; DHH1; Dmel\CG6539; DmRH22; gemin3; GEMIN3; l(3)rL562
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Involved in flight behavior; neuromuscular junction development; and protein-RNA complex assembly. Located in Cajal body; Gemini of coiled bodies; and cytoplasm. Part of SMN complex and cytoplasmic U snRNP body. Is expressed in eye disc; nurse cell; and oocyte. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gem3 in Genome Data Viewer
Location:
67E3-67E3; 3-33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10459081..10463101, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10452181..10456201, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 67b Neighboring gene Ionotropic receptor 67c Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis. Cauchi RJ. BMC Res Notes, 2012 Feb 23. PMID 22361416, Free PMC Article
  2. When one plus one equals three: biochemistry and bioinformatics combine to answer complex questions. Kroiss M, et al. Fly (Austin), 2009 Jul-Sep. PMID 19625772
  3. Gem formation upon constitutive Gemin3 overexpression in Drosophila. Cauchi RJ. Cell Biol Int, 2011 Dec. PMID 21627586
  4. SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila. Praveen K, et al. PLoS Genet, 2014 Aug. PMID 25144193, Free PMC Article
  5. Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. Borg RM, et al. PLoS One, 2015. PMID 26098872, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.
    Title: SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.
  2. Data show that Gemin3 was required for the completion of oogenesis and its loss led to egg polarity defects, oocyte mislocalisation, and abnormal chromosome morphology.
    Title: Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis.
  3. Gemin3 overexpression in Drosophila
    Title: Gem formation upon constitutive Gemin3 overexpression in Drosophila.
  4. Gemin2, Gemin3 and Gemin5 colocalise with SMN in U bodies
    Title: Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies.
  5. Results demonstrate the conservation of Gemin3 (Gem3) protein function in metazoan snRNP assembly and reveal that loss of either survival motor neuron (Smn) or Gemin3 can contribute to neuromuscular dysfunction.
    Title: Gemin3 is an essential gene required for larval motor function and pupation in Drosophila.
  6. Drosophila Gemin3 is required for larval development and motor function.
    Title: A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flight behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-RNA complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Cajal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Gemini of coiled bodies IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMN complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SMN complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic U snRNP body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gemin 3
Names
CG6539-PA
CG6539-PB
DEAD/DEAH RNA helicase 1
Gem3-PA
Gem3-PB
dGemin3
gemin3
NP_001261678.1
NP_524019.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10459081..10463101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274749.1 → NP_001261678.1  gemin 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261678.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3C4
    Conserved Domains (3) summary
    COG0513
    Location:24 → 541
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:259 → 367
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:27 → 228
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_079295.4 → NP_524019.1  gemin 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524019.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3C4
    Related
    FBpp0076021
    Conserved Domains (3) summary
    COG0513
    Location:24 → 541
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:259 → 367
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:27 → 228
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3C4 Q9V3C4

Gene LinkOut

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