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vnc variable nurse cells [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39175, updated on 9-Dec-2024

Summary

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Official Symbol
vncprovided by FlyBase
Official Full Name
variable nurse cellsprovided by FlyBase
Primary source
FLYBASE:FBgn0263251
Locus tag
Dmel_CG11989
See related
AllianceGenome:FB:FBgn0263251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ard1; Ard1; ARD1; CG11989; dArd1; DmAAF50178; Dmel\CG11989; dNaa10; Dromel_CG11989_FBtr0076348_ard1_mORF; l(3)67BDk; Naa10; NAA10; Naa10/11
Summary
Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Involved in oogenesis. Part of NatA complex. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to several human genes including NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See vnc in Genome Data Viewer
Location:
67D2-67D2; 3-32 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9972312..9974023)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9965412..9967123)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Death regulator Nedd2-like caspase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45876 Neighboring gene defective proboscis extension response 6 Neighboring gene long non-coding RNA:CR45877

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental roles of protein N-terminal acetylation. Silva RD, et al. Proteomics, 2015 Jul. PMID 25920796
  2. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. Polevoda B, et al. J Mol Biol, 2003 Jan 24. PMID 12507466
  3. Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex. Wang Y, et al. Dev Dyn, 2010 Nov. PMID 20882681, Free PMC Article
  4. Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila. Williams BC, et al. Curr Biol, 2003 Dec 2. PMID 14653991
  5. Genetic analysis of chromosomal region 67A-D of Drosophila melanogaster. Leicht BG, et al. Genetics, 1988 Jul. PMID 3136051, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptide alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-serine-alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatA complex IEA
Inferred from Electronic Annotation
more info
  
part_of NatA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of protein acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
variable nurse cells
Names
Ard1
CG11989-PA
CG11989-PB
CG11989-PC
CG11989-PD
CG11989-PE
N(alpha)-acetyltransferase 10
arrest defective 1
arrest defective1
lethal (3) 67BDk
variable nurse cell
vnc-PA
vnc-PB
vnc-PC
vnc-PD
vnc-PE
NP_648378.1
NP_729581.1
NP_729582.1
NP_729583.1
NP_729584.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9972312..9974023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168391.2 → NP_729582.1  variable nurse cells, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729582.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT75
    Related
    FBpp0076079
    Conserved Domains (1) summary
    COG0456
    Location:1 → 151
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  2. NM_140121.2 → NP_648378.1  variable nurse cells, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT75
    Related
    FBpp0076077
    Conserved Domains (1) summary
    COG0456
    Location:1 → 151
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  3. NM_168390.2 → NP_729581.1  variable nurse cells, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729581.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT75
    Related
    FBpp0076078
    Conserved Domains (1) summary
    COG0456
    Location:1 → 151
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  4. NM_168393.2 → NP_729584.1  variable nurse cells, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729584.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT75
    Related
    FBpp0076080
    Conserved Domains (1) summary
    COG0456
    Location:1 → 151
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

  5. NM_168392.2 → NP_729583.1  variable nurse cells, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729583.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT75
    Related
    FBpp0076081
    Conserved Domains (1) summary
    COG0456
    Location:1 → 151
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VT75 Q9VT75

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