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Ae2 Anion exchanger 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39147, updated on 9-Dec-2024

Summary

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Official Symbol
Ae2provided by FlyBase
Official Full Name
Anion exchanger 2provided by FlyBase
Primary source
FLYBASE:FBgn0036043
Locus tag
Dmel_CG8177
See related
AllianceGenome:FB:FBgn0036043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ae2; anon-EST:Posey259; BcDNA:RE59468; CG8177; DAE; Dmel\CG8177
Summary
Predicted to enable transmembrane transporter activity. Involved in intracellular pH reduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult brain; adult head; embryonic/larval midgut; ganglia; and larval midgut enterocyte. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; osteopetrosis; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)); SLC4A2 (solute carrier family 4 member 2); and SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ae2 in Genome Data Viewer
Location:
67C7-67C8; 3-31 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9763544..9786466)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9756644..9779566)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44348 Neighboring gene long non-coding RNA:CR45407 Neighboring gene uncharacterized protein Neighboring gene Z band alternatively spliced PDZ-motif protein 67 Neighboring gene Insulin-like peptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila anion exchanger 2 is required for proper ovary development and oogenesis. Benitez M, et al. Dev Biol, 2019 Aug 15. PMID 31071312, Free PMC Article
  2. The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton. Dubreuil RR, et al. J Negat Results Biomed, 2010 Jun 23. PMID 20573195, Free PMC Article
  3. Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. Romero MF, et al. J Biol Chem, 2000 Aug 11. PMID 10827195
  4. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. Ulmschneider B, et al. J Cell Biol, 2016 Nov 7. PMID 27821494, Free PMC Article
  5. Long-range targeted manipulation of the Drosophila genome by site-specific integration and recombinational resolution. Wesolowska N, et al. Genetics, 2013 Feb. PMID 23150601, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ae2 null flies have smaller ovaries, reduced fertility, and impaired follicle formation.
    Title: Drosophila anion exchanger 2 is required for proper ovary development and oogenesis.
  2. The well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in Drosophila.
    Title: The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular pH reduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anion exchanger 2
Names
Ae2-PA
Ae2-PB
Ae2-PC
Ae2-PD
Ae2-PE
Ae2-PF
Ae2-PG
Ae2-PH
Ae2-PI
Ae2-PJ
Ae2-PK
Ae2-PL
Ae2-PM
CG8177-PA
CG8177-PB
CG8177-PC
CG8177-PD
CG8177-PE
CG8177-PF
CG8177-PG
CG8177-PH
CG8177-PI
CG8177-PJ
CG8177-PK
CG8177-PL
CG8177-PM
drosophila anion exchanger

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9763544..9786466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274724.2 → NP_001261653.1  anion exchanger 2, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEQ4, Q6NL70
    Conserved Domains (3) summary
    TIGR00834
    Location:269 → 1209
    ae; anion exchange protein
    pfam00955
    Location:640 → 1141
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:296 → 560
    Band_3_cyto; Band 3 cytoplasmic domain

  2. NM_168371.3 → NP_729548.1  anion exchanger 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD6
    Related
    FBpp0076046
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1200
    ae; anion exchange protein
    pfam00955
    Location:631 → 1132
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 551
    Band_3_cyto; Band 3 cytoplasmic domain

  3. NM_206312.3 → NP_996034.1  anion exchanger 2, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q7KUD6
    Conserved Domains (3) summary
    TIGR00834
    Location:225 → 1165
    ae; anion exchange protein
    pfam00955
    Location:596 → 1097
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:252 → 516
    Band_3_cyto; Band 3 cytoplasmic domain

  4. NM_168369.2 → NP_729546.1  anion exchanger 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729546.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q9VT48
    Related
    FBpp0076048
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1267
    ae; anion exchange protein
    pfam00955
    Location:698 → 1199
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 618
    Band_3_cyto; Band 3 cytoplasmic domain

  5. NM_206314.3 → NP_996036.1  anion exchanger 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996036.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD6
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1200
    ae; anion exchange protein
    pfam00955
    Location:631 → 1132
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 551
    Band_3_cyto; Band 3 cytoplasmic domain

  6. NM_206311.2 → NP_996033.1  anion exchanger 2, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996033.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q7KUD7
    Conserved Domains (3) summary
    TIGR00834
    Location:225 → 1232
    ae; anion exchange protein
    pfam00955
    Location:663 → 1164
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:252 → 583
    Band_3_cyto; Band 3 cytoplasmic domain

  7. NM_206313.2 → NP_996035.1  anion exchanger 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996035.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD6
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1200
    ae; anion exchange protein
    pfam00955
    Location:631 → 1132
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 551
    Band_3_cyto; Band 3 cytoplasmic domain

  8. NM_168372.2 → NP_729549.1  anion exchanger 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729549.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD6
    Related
    FBpp0076047
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1200
    ae; anion exchange protein
    pfam00955
    Location:631 → 1132
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 551
    Band_3_cyto; Band 3 cytoplasmic domain

  9. NM_168370.3 → NP_729547.1  anion exchanger 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729547.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD6
    Related
    FBpp0076049
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1200
    ae; anion exchange protein
    pfam00955
    Location:631 → 1132
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 551
    Band_3_cyto; Band 3 cytoplasmic domain

  10. NM_140100.2 → NP_648357.1  anion exchanger 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q9VT48
    Related
    FBpp0076050
    Conserved Domains (3) summary
    TIGR00834
    Location:260 → 1267
    ae; anion exchange protein
    pfam00955
    Location:698 → 1199
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:287 → 618
    Band_3_cyto; Band 3 cytoplasmic domain

  11. NM_168373.3 → NP_729550.1  anion exchanger 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729550.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD5
    Related
    FBpp0076052
    Conserved Domains (3) summary
    TIGR00834
    Location:220 → 1227
    ae; anion exchange protein
    pfam00955
    Location:658 → 1159
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:247 → 578
    Band_3_cyto; Band 3 cytoplasmic domain

  12. NM_168374.2 → NP_729551.1  anion exchanger 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729551.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL70, Q8IQD4
    Related
    FBpp0076051
    Conserved Domains (3) summary
    TIGR00834
    Location:220 → 1160
    ae; anion exchange protein
    pfam00955
    Location:591 → 1092
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:247 → 511
    Band_3_cyto; Band 3 cytoplasmic domain

  13. NM_001169931.2 → NP_001163402.1  anion exchanger 2, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163402.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PD2
    Conserved Domains (1) summary
    pfam07565
    Location:247 → 346
    Band_3_cyto; Band 3 cytoplasmic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEQ4 M9PEQ4
Q7KUD6 Q7KUD6
Q7KUD7 Q7KUD7
Q86PD2 Q86PD2
Q8IQD4 Q8IQD4
Q8IQD5 Q8IQD5
Q8IQD6 Q8IQD6
Q8MRK3 Q8MRK3
Q95SW2 Q95SW2
Q9VT48 Q9VT48

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