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defl deflated [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39141, updated on 9-Dec-2024

Summary

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Official Symbol
deflprovided by FlyBase
Official Full Name
deflatedprovided by FlyBase
Primary source
FLYBASE:FBgn0036038
Locus tag
Dmel_CG18176
See related
AllianceGenome:FB:FBgn0036038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18176; Dmel\CG18176; Int7; IntS7
Summary
Involved in snRNA 3'-end processing. Located in cytoplasm and nucleus. Is expressed in embryonic/larval gut; larval central nervous system; and organism. Orthologous to human INTS7 (integrator complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See defl in Genome Data Viewer
Location:
67C5-67C5; 3-31 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9723423..9726706)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9716523..9719806)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nbs Neighboring gene N(alpha)-acetyltransferase 60 Neighboring gene ATP synthase, subunit B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phenotypic analysis of deflated/Ints7 function in Drosophila development. Rutkowski RJ, et al. Dev Dyn, 2009 May. PMID 19326441
  2. Nucleosome organization in the Drosophila genome. Mavrich TN, et al. Nature, 2008 May 15. PMID 18408708, Free PMC Article
  3. Epigenetic telomere protection by Drosophila DNA damage response pathways. Oikemus SR, et al. PLoS Genet, 2006 May. PMID 16710445, Free PMC Article
  4. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
  5. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
deflated
Names
CG18176-PA
defl-PA
integrator 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9723423..9726706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140095.4 → NP_648352.2  deflated [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648352.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q961P9, Q9VT41
    Related
    FBpp0076132
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VT41.1 Q9VT41

Gene LinkOut

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