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vsg visgun [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39137, updated on 4-Jan-2025

Summary

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Official Symbol
vsgprovided by FlyBase
Official Full Name
visgunprovided by FlyBase
Primary source
FLYBASE:FBgn0045823
Locus tag
Dmel_CG16707
See related
AllianceGenome:FB:FBgn0045823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.164; BEST:GH15083; CG16707; Dmel\CG16707; GH15083; Vsg
Summary
Involved in behavioral response to ethanol; long-term memory; and regulation of cell population proliferation. Located in cytoplasmic vesicle; female germline ring canal; and somatic ring canal. Is expressed in several structures, including adult brain cell body rind; dorsal ectoderm; dorsal epidermis primordium; embryonic/larval crystal cell; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 66. Orthologous to several human genes including CD164 (CD164 molecule) and CD164L2 (CD164 molecule like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See vsg in Genome Data Viewer
Location:
67C5-67C5; 3-31 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9714324..9717716)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9707424..9710816)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SH3 and PX domain containing 1 Neighboring gene small non-coding RNA 838 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nbs

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor. Xu Y, et al. Nature, 2022 Oct. PMID 36171290, Free PMC Article
  2. The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation. Zhou GQ, et al. J Cell Biochem, 2006 Dec 1. PMID 16924678
  3. Intercellular protein movement in syncytial Drosophila follicle cells. Airoldi SJ, et al. J Cell Sci, 2011 Dec 1. PMID 22135360, Free PMC Article
  4. The Gene CG6767 Affects Olfactory Behavior in Drosophila melanogaster. Brown EB, et al. Behav Genet, 2019 May. PMID 30710192
  5. The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants. Akalal DB, et al. J Neurosci, 2011 Apr 13. PMID 21490205, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
    Title: CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
  2. Results demonstrate that endolyn is an evolutionarily conserved sialomucin fundamentally involved in cell proliferation in both the human and Drosophila melanogaster.
    Title: The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in female germline ring canal IDA
Inferred from Direct Assay
more info
 PubMed 
located_in somatic ring canal IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
visgun
Names
CG16707-PA
CG16707-PB
CG16707-PC
CG16707-PD
CG16707-PE
endolyn
vsg-PA
vsg-PB
vsg-PC
vsg-PD
vsg-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9714324..9717716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168362.2 → NP_729534.1  visgun, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729534.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT37
    Related
    FBpp0076129
    Conserved Domains (1) summary
    pfam05283
    Location:146 → 183
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

  2. NM_168363.2 → NP_729535.1  visgun, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729535.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0D8
    Related
    FBpp0076127
    Conserved Domains (1) summary
    pfam05283
    Location:145 → 182
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

  3. NM_140092.2 → NP_648349.1  visgun, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648349.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT37
    Related
    FBpp0076130
    Conserved Domains (1) summary
    pfam05283
    Location:146 → 183
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

  4. NM_168364.2 → NP_729536.1  visgun, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0D8
    Related
    FBpp0076128
    Conserved Domains (1) summary
    pfam05283
    Location:145 → 182
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

  5. NM_001274717.1 → NP_001261646.1  visgun, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261646.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHX2
    Conserved Domains (1) summary
    pfam05283
    Location:145 → 182
    MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHX2 M9PHX2
Q8I0D8 Q8I0D8
Q95T68 Q95T68
Q9VT37 Q9VT37

Gene LinkOut

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