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SH3PX1 SH3 and PX domain containing 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39136, updated on 4-Jan-2025

Summary

Official Symbol
SH3PX1provided by FlyBase
Official Full Name
SH3 and PX domain containing 1provided by FlyBase
Primary source
FLYBASE:FBgn0040475
Locus tag
Dmel_CG6757
See related
AllianceGenome:FB:FBgn0040475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6757; Dmel\CG6757; DmSNX18; DSH3PX; dSH3PX1; DSH3PX1; p63; sh3px1; Sh3px1; Snx18
Summary
Enables kinase binding activity and protein-macromolecule adaptor activity. Involved in several processes, including cellular response to hypoxia; lamellipodium assembly; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in several cellular components, including neuronal cell body; presynaptic membrane; and subsynaptic reticulum. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval midgut; larval neurons; and larval ventral nerve cord. Used to study colorectal cancer. Orthologous to several human genes including SNX9 (sorting nexin 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See SH3PX1 in Genome Data Viewer
Location:
67C5-67C5; 3-31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9710422..9713827, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9703522..9706927, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene visgun Neighboring gene small non-coding RNA 838 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic active zone organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in subsynaptic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in subsynaptic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SH3 and PX domain containing 1
Names
CG6757-PA
SH3PX1 ortholog
SH3PX1-PA

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9710422..9713827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140091.4NP_648348.1  SH3 and PX domain containing 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648348.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NCC3, Q9VT36
    Related
    FBpp0076142
    Conserved Domains (3) summary
    cd06862
    Location:219343
    PX_SNX9_18_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 9 and 18
    cd07626
    Location:362564
    BAR_SNX9_like; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 9 and Similar Proteins
    cd11763
    Location:459
    SH3_SNX9_like; Src Homology 3 domain of Sorting Nexin 9 and similar proteins